Parkinson’s Disease - A Simplified Explanation

A ‘Clogged up’ Brain.

In Parkinson’s Disease, proteins (alpha-synuclein) in the brain begin to fail doing their normal job, and instead of folding nicely and neatly like they are designed to, they ‘mis-fold’ and create clumps. These clumps then behave as though they are ‘toxic’ - which can begin to interfere with our nerve cells, choke and disrupt function, eventually triggering cell death.

These proteins are important, as they help our nerves in the brain to send the signal we need to operate as human beings. A few misguided cells are no issue - but if enough critical functionals fail the whole system starts to break down.

NeuroInflammation

Our immune system is our army against invaders. In the brain, we have a specially ‘trained’ squad (microglia), which patrols our brain for invaders, but also damage. Like all our immune system, this army can become an aggressor, but for the majority of the time, it needs to show ‘tolerance’. Invaders may be friendly and reside happily within our internal environment - where no aggression or escalation is necessary. Presenting with tolerance versus attack can be a fine line, and chronic stress, chronic infection elsewhere in the body may trigger the immune system to act. Interestingly, we’re exposed to and often experience significant challenge by bacteria elsewhere in the body, such as in the mouth, in the gut and even the bladder. Research into how this connects with our immune system and brain is ongoing, but at early stages.

Our immune system is highly complex, but it’s armoury surprisingly simple: Fire and aim, releasing chemicals and breaking up (by engulfing) the enemy. However, when this is approach is aimed at our own tissue, perhaps as an attempt to fix an issue of which they don’t quite have the right armoury for, damage and destruction occurs. This creates inflammation that burns and smoulders for years, prior to symptoms - and long before your diagnosis.

Our Focus

Our focus is on lifestyle interventions and prevention, with therapies that safeguards health generally, and in particularly in areas that we know have a direct connection with what occurs in our neuron’s and brain proteins. We hope to boosts the brain’s ability to prevent and clear out early default function, before more severe and irreversible damage sets in.

Our objective is to reduce chronic inflammation body wide, and locate sources of infection or toxins early to help calm the immune system and protect the brain.